Active Pharmaceutical Ingredient Directory

2,594+ active pharmaceutical ingredients with verified FDA Drug Master File suppliers, CAS numbers, chemical identity and US patent-expiry dates — screened against live FDA enforcement data.

API patent cliff — upcoming US expiries

APIs whose latest listed US patent or exclusivity (FDA Orange Book) expires soonest — the moment generic sourcing opens up. Plan your sourcing pipeline ahead of the cliff.

Get the API patent-cliff watchlist

Monthly digest of APIs coming off US patent/exclusivity — so you can line up qualified suppliers before generics open up. No spam; unsubscribe anytime.

Active ingredientNext US expiry
Tiopronin27 Jun 2026
Levonorgestrel28 Jun 2026
Perampanel30 Jun 2026
Iohexol25 Jul 2026
Alogliptin Benzoate26 Jul 2026
Fedratinib15 Aug 2026
Aliskiren18 Aug 2026
Sofosbuvir27 Aug 2026
Escitalopram Oxalate15 Sept 2026
Phentolamine24 Sept 2026
Atogepant27 Sept 2026
Miglustat27 Sept 2026
Donepezil3 Oct 2026
Binimetinib10 Oct 2026
Treosulfan11 Oct 2026
Ipratropium12 Oct 2026
Pilocarpine16 Oct 2026
Tenapanor16 Oct 2026
Edoxaban17 Oct 2026
Pimozide17 Oct 2026
Loxapine22 Oct 2026
Bupivacaine9 Nov 2026
Enzalutamide17 Nov 2026
Ropivacaine28 Nov 2026
Dasatinib5 Dec 2026
Pantoprazole7 Dec 2026
Golodirsen12 Dec 2026
Travoprost13 Dec 2026
Empagliflozin20 Dec 2026
Linagliptin20 Dec 2026
Telavancin1 Jan 2027
Tapentadol3 Jan 2027
Methylene Blue8 Jan 2027
Abrocitinib14 Jan 2027
Olodaterol19 Jan 2027
Erdafitinib19 Jan 2027
Fidaxomicin24 Jan 2027
Regadenoson2 Feb 2027
Balsalazide24 Feb 2027
Clobetasol Propionate4 Mar 2027
Nintedanib6 Mar 2027
Fluticasone Propionate15 Mar 2027
Epoprostenol15 Mar 2027
Bempedoic Acid22 Mar 2027
Oxcarbazepine12 Apr 2027
Naloxone18 Apr 2027
Florbetapir F 1829 Apr 2027
Pregabalin1 May 2027
Capmatinib5 May 2027
Olaparib7 May 2027
Ripretinib14 May 2027
Artesunate25 May 2027
Tirbanibulin6 Jun 2027
Bedaquiline20 Jun 2027
Octreotide25 Jun 2027
Darunavir25 Jun 2027
Desvenlafaxine4 Jul 2027
Indigotindisulfonate7 Jul 2027
Eribulin7 Jul 2027
Cannabidiol30 Jul 2027

Most-supplied APIs

Rivaroxaban
CAS 366789-02-8 · 57 suppliers
Pantoprazole
CAS 102625-70-7 · 53 suppliers
Apixaban
CAS 503612-47-3 · 51 suppliers
Sitagliptin
CAS 486460-32-6 · 50 suppliers
Semaglutide
CAS 910463-68-2 · 48 suppliers
Aripiprazole
CAS 129722-12-9 · 45 suppliers
Atorvastatin
CAS 134523-00-5 · 44 suppliers
Telmisartan
CAS 144701-48-4 · 43 suppliers
Empagliflozin
CAS 864070-44-0 · 42 suppliers
Amoxicillin
CAS 26787-78-0 · 41 suppliers
Pregabalin
CAS 148553-50-8 · 40 suppliers
Clopidogrel
CAS 113665-84-2 · 40 suppliers
Bosentan
CAS 147536-97-8 · 40 suppliers
Ampicillin
CAS 69-53-4 · 40 suppliers
Esomeprazole
CAS 119141-88-7 · 39 suppliers
Olmesartan Medoxomil
CAS 144689-63-4 · 38 suppliers
Valsartan
CAS 137862-53-4 · 37 suppliers
Levetiracetam
CAS 102767-28-2 · 37 suppliers
Losartan
CAS 114798-26-4 · 36 suppliers
Lurasidone Hydrochloride
CAS 367514-88-3 · 35 suppliers
Ticagrelor
CAS 274693-27-5 · 35 suppliers
Lansoprazole
CAS 103577-45-3 · 35 suppliers
Amlodipine
CAS 88150-42-9 · 34 suppliers
Rosuvastatin
CAS 147098-20-2 · 34 suppliers
Lamotrigine
CAS 84057-84-1 · 33 suppliers
Paclitaxel
CAS 33069-62-4 · 33 suppliers
Atenolol
CAS 29122-68-7 · 33 suppliers
Omeprazole
CAS 73590-58-6 · 33 suppliers
Lacosamide
CAS 175481-36-4 · 33 suppliers
Mirabegron
CAS 223673-61-8 · 33 suppliers
Enzalutamide
CAS 915087-33-1 · 32 suppliers
Ibuprofen
CAS 15687-27-1 · 32 suppliers
Dabigatran Etexilate Mesylate
31 suppliers
Nifedipine
CAS 21829-25-4 · 30 suppliers
Celecoxib
CAS 169590-42-5 · 30 suppliers
Mesalamine
CAS 89-57-6 · 30 suppliers
Pirfenidone
CAS 53179-13-8 · 29 suppliers
Solifenacin Succinate
CAS 242478-38-2 · 29 suppliers
Metoprolol
CAS 37350-58-6 · 29 suppliers
Quetiapine Fumarate
CAS 111974-72-2 · 29 suppliers
Linagliptin
CAS 668270-12-0 · 29 suppliers
Topiramate
CAS 97240-79-4 · 29 suppliers
Tofacitinib
CAS 477600-75-2 · 29 suppliers
Anastrozole
CAS 120511-73-1 · 28 suppliers
Potassium
CAS 7440-09-7 · 28 suppliers
Acyclovir
28 suppliers
Metformin
CAS 657-24-9 · 28 suppliers
Allopurinol
CAS 315-30-0 · 28 suppliers
Docetaxel
CAS 114977-28-5 · 28 suppliers
Risperidone
CAS 106266-06-2 · 27 suppliers
Levofloxacin
CAS 100986-85-4 · 27 suppliers
Methocarbamol
CAS 532-03-6 · 27 suppliers
Escitalopram Oxalate
CAS 219861-08-2 · 27 suppliers
Irbesartan
CAS 138402-11-6 · 27 suppliers
Chlorthalidone
CAS 77-36-1 · 27 suppliers
Ranolazine
CAS 95635-55-5 · 27 suppliers
Capecitabine
CAS 154361-50-9 · 27 suppliers
Olanzapine
CAS 132539-06-1 · 27 suppliers
Chlorhexidine
27 suppliers
Duloxetine
CAS 116539-59-4 · 27 suppliers
Search all 2,594 APIs

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