Active Pharmaceutical Ingredient Directory

4,348+ active pharmaceutical ingredients with verified FDA Drug Master File suppliers, CAS numbers, chemical identity and US patent-expiry dates — screened against live FDA enforcement data.

API patent cliff — upcoming US expiries

APIs whose latest listed US patent or exclusivity (FDA Orange Book) expires soonest — the moment generic sourcing opens up. Plan your sourcing pipeline ahead of the cliff.

Get the API patent-cliff watchlist

Monthly digest of APIs coming off US patent/exclusivity — so you can line up qualified suppliers before generics open up. No spam; unsubscribe anytime.

Active ingredientNext US expiry
Fedratinib16 Aug 2026
Aliskiren19 Aug 2026
Difelikefalin23 Aug 2026
Sofosbuvir28 Aug 2026
Escitalopram Oxalate16 Sept 2026
Phentolamine25 Sept 2026
Atogepant28 Sept 2026
Miglustat28 Sept 2026
Technetium TC-99M Labeled Carbon29 Sept 2026
Sinecatechins2 Oct 2026
Sinecatechins2 Oct 2026
Donepezil4 Oct 2026
Afamelanotide8 Oct 2026
Binimetinib11 Oct 2026
Treosulfan12 Oct 2026
Ipratropium13 Oct 2026
Pilocarpine17 Oct 2026
Tenapanor17 Oct 2026
Edoxaban18 Oct 2026
Pimozide18 Oct 2026
Treprostinil Diolamine18 Oct 2026
Loxapine23 Oct 2026
Bupivacaine9 Nov 2026
Enzalutamide17 Nov 2026
Givosiran20 Nov 2026
Sitagliptin24 Nov 2026
Ropivacaine28 Nov 2026
Dasatinib5 Dec 2026
Pantoprazole7 Dec 2026
Romidepsin7 Dec 2026
Azilsartan Kamedoxomil12 Dec 2026
Golodirsen12 Dec 2026
Travoprost13 Dec 2026
Pasireotide Diaspartate14 Dec 2026
Albuterol19 Dec 2026
Empagliflozin20 Dec 2026
Linagliptin20 Dec 2026
Brilliant Blue G20 Dec 2026
Telavancin1 Jan 2027
Tapentadol3 Jan 2027
Methylene Blue Anhydrous8 Jan 2027
Methylene Blue8 Jan 2027
Abrocitinib14 Jan 2027
Olodaterol19 Jan 2027
Erdafitinib19 Jan 2027
Fidaxomicin24 Jan 2027
Regadenoson2 Feb 2027
Vortioxetine23 Feb 2027
Balsalazide24 Feb 2027
Clobetasol Propionate4 Mar 2027
Nintedanib6 Mar 2027
Fluticasone Propionate15 Mar 2027
Epoprostenol15 Mar 2027
Bempedoic Acid22 Mar 2027
Tenofovir Alafenamide27 Mar 2027
Oxcarbazepine13 Apr 2027
Naloxone19 Apr 2027
Florbetapir F 1830 Apr 2027
Pregabalin2 May 2027
Capmatinib6 May 2027

Most-supplied APIs

Rivaroxaban
CAS 366789-02-8 · 59 suppliers
Semaglutide
CAS 910463-68-2 · 52 suppliers
Apixaban
CAS 503612-47-3 · 52 suppliers
Sitagliptin
CAS 486460-32-6 · 51 suppliers
Aripiprazole
CAS 129722-12-9 · 43 suppliers
Empagliflozin
CAS 864070-44-0 · 42 suppliers
Ampicillin
CAS 69-53-4 · 40 suppliers
Telmisartan
CAS 144701-48-4 · 40 suppliers
Clopidogrel
CAS 113665-84-2 · 39 suppliers
Pregabalin
CAS 148553-50-8 · 39 suppliers
Levetiracetam
CAS 102767-28-2 · 38 suppliers
Amoxicillin
CAS 26787-78-0 · 38 suppliers
Olmesartan Medoxomil
CAS 144689-63-4 · 36 suppliers
Ticagrelor
CAS 274693-27-5 · 35 suppliers
Esomeprazole
CAS 119141-88-7 · 35 suppliers
Valsartan
CAS 137862-53-4 · 35 suppliers
Atorvastatin
CAS 134523-00-5 · 34 suppliers
Rosuvastatin
CAS 147098-20-2 · 34 suppliers
Paracetamol
CAS 103-90-2 · 33 suppliers
Lansoprazole
CAS 103577-45-3 · 32 suppliers
Tirzepatide
32 suppliers
Omeprazole
CAS 73590-58-6 · 32 suppliers
Lurasidone Hydrochloride
CAS 367514-88-3 · 32 suppliers
Dabigatran Etexilate Mesylate
32 suppliers
Amlodipine
CAS 88150-42-9 · 32 suppliers
Mirabegron
CAS 223673-61-8 · 31 suppliers
Lamotrigine
CAS 84057-84-1 · 31 suppliers
Lacosamide
CAS 175481-36-4 · 31 suppliers
Escitalopram Oxalate
CAS 219861-08-2 · 30 suppliers
Atenolol
CAS 29122-68-7 · 30 suppliers
Acyclovir
30 suppliers
Enzalutamide
CAS 915087-33-1 · 29 suppliers
Quetiapine Fumarate
CAS 111974-72-2 · 29 suppliers
Docetaxel Anhydrous
CAS 114977-28-5 · 29 suppliers
Duloxetine
CAS 116539-59-4 · 29 suppliers
Solifenacin Succinate
CAS 242478-38-2 · 29 suppliers
Losartan
CAS 114798-26-4 · 29 suppliers
Paclitaxel
CAS 33069-62-4 · 29 suppliers
Ibuprofen
CAS 15687-27-1 · 29 suppliers
Pantoprazole
CAS 102625-70-7 · 28 suppliers
Linagliptin
CAS 668270-12-0 · 28 suppliers
Sugammadex Sodium
27 suppliers
Irbesartan
CAS 138402-11-6 · 27 suppliers
Pirfenidone
CAS 53179-13-8 · 27 suppliers
Trimethoprim
CAS 738-70-5 · 27 suppliers
Tofacitinib Citrate
CAS 540737-29-9 · 27 suppliers
Paliperidone
CAS 144598-75-4 · 27 suppliers
Oxcarbazepine
CAS 28721-07-5 · 27 suppliers
Celecoxib
CAS 169590-42-5 · 27 suppliers
Propranolol Hydrochloride
CAS 318-98-9 · 27 suppliers
Gabapentin
CAS 60142-96-3 · 27 suppliers
Mesalamine
CAS 89-57-6 · 27 suppliers
Nifedipine
CAS 21829-25-4 · 27 suppliers
Pantoprazole Sodium
27 suppliers
Topiramate
CAS 97240-79-4 · 26 suppliers
Potassium
CAS 7440-09-7 · 26 suppliers
Metoprolol
CAS 37350-58-6 · 26 suppliers
Chlorhexidine
26 suppliers
Quetiapine
CAS 111974-69-7 · 26 suppliers
Heparin
26 suppliers
Search all 4,348 APIs

Browse all 4,348 APIs A–Z

Every active pharmaceutical ingredient we track, alphabetically — each with its DMF / CEP suppliers, CAS number and US patent status.

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