Nintedanib

Overview

Nintedanib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL502835).

Patent & exclusivity (US)

Per the FDA Orange Book (12 approved US products), the latest listed US patent on Nintedanib expires 7 Dec 2029 and exclusivity 6 Mar 2027. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate

Canonical SMILES

CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N/C(=C\3/C4=C(C=C(C=C4)C(=O)OC)NC3=O)/C5=CC=CC=C5

InChIKey

XZXHXSATPCNXJR-ZIADKAODSA-N