Naloxone

Overview

Naloxone is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL80).

API suppliers (9)

Suppliers of Naloxone backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• NORAMCO INC3 active DMF
• Sun Pharmaceutical Industries LimitedIndia2 active DMF
• SPECGX LLCUnited States1 active DMF
• SPECGX LLCUnited States1 active DMF
• SIEGFRIED USA LLC1 active DMF
• SPECGX LLCUnited States1 active DMF
• SIEGFRIED USA LLC1 active DMF
• SANOFI AVENTIS CHIMIE
• SIGMA F AND D DIV LTD

Patent & exclusivity (US)

Per the FDA Orange Book (38 approved US products), the latest listed US patent on Naloxone expires 13 Jun 2041 and exclusivity 18 Apr 2027. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

Canonical SMILES

C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O

InChIKey

UZHSEJADLWPNLE-GRGSLBFTSA-N