Nifurtimox

Overview

Nifurtimox is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL290960).

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Nifurtimox expires — and exclusivity 6 Aug 2027. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(E)-N-(3-methyl-1,1-dioxo-1,4-thiazinan-4-yl)-1-(5-nitrofuran-2-yl)methanimine

Canonical SMILES

CC1CS(=O)(=O)CCN1/N=C/C2=CC=C(O2)[N+](=O)[O-]

InChIKey

ARFHIAQFJWUCFH-IZZDOVSWSA-N