Methylene Blue

Overview

Methylene Blue is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL550495).

API suppliers (9)

Suppliers of Methylene Blue evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• PROVEPHARM SASFrance1 active DMF
• MIKROCHEM SPOL SROSlovakia1 active DMF
• PHARMAZELL GMBHGermany1 active DMF GMP on record
• MACSEN DRUGSIndia1 active DMF
• CHEMCON GMBHGermany1 active DMF GMP on record
• Sichuan Qingmu Pharmaceutical Co., Ltd.China1 active DMF
• ICROM SRLItaly1 active DMF GMP on record
• CHEMWERTH INCFrance1 active DMF
• KALINTIS HEALTHCARE PVT LTDIndia1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (12 approved US products), the latest listed US patent on Methylene Blue expires — and exclusivity 8 Jan 2027. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride;trihydrate

Canonical SMILES

CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.O.O.O.[Cl-]

InChIKey

XQAXGZLFSSPBMK-UHFFFAOYSA-M