Darunavir

Overview

Darunavir is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1323).

API suppliers (4)

Suppliers of Darunavir backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Cipla USA, Inc.USA3 active DMF
• Laurus Labs LimitedIndia1 active DMF
• MATRIX PHARMACORP PRIVATE LTD1 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China

Patent & exclusivity (US)

Per the FDA Orange Book (28 approved US products), the latest listed US patent on Darunavir expires 25 Jun 2027. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate

Canonical SMILES

CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N

InChIKey

CJBJHOAVZSMMDJ-HEXNFIEUSA-N