Avatrombopag
Overview
Avatrombopag is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2103883).
API suppliers (2)
Suppliers of Avatrombopag evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.
1 of 2 holds a GMP certificate on record in the EU or UK registers
- Zhejiang Ausun Pharmaceutical Co., Ltd.China2 active DMF GMP on record
- APICHEM Laboratories Private LimitedIndia1 active DMF
Patent & exclusivity (US)
Per the FDA Orange Book (2 approved US products), the latest listed US patent on Avatrombopag expires 28 Jul 2027 and exclusivity 24 Jul 2032. Generic API sourcing typically opens up once these lapse.
Chemical identity
- IUPAC name
- 1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]-2-pyridinyl]piperidine-4-carboxylic acid
- Canonical SMILES
- C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl
- InChIKey
- OFZJKCQENFPZBH-UHFFFAOYSA-N
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