Tenofovir Alafenamide

CAS 379270-37-8 6 API suppliersSmall Molecule

Overview

Tenofovir Alafenamide is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2107825).

API suppliers (6)

Suppliers of Tenofovir Alafenamide evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

Where these suppliers are
India3USA1United States1China1

3 of 6 hold a GMP certificate on record in the EU or UK registers

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Tenofovir Alafenamide expires 15 Feb 2033 and exclusivity 27 Mar 2027. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name
propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate
Canonical SMILES
C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3
InChIKey
LDEKQSIMHVQZJK-CAQYMETFSA-N
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