Tenofovir Alafenamide

Overview

Tenofovir Alafenamide is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2107825).

API suppliers (6)

Suppliers of Tenofovir Alafenamide backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Lupin LimitedIndia1 active DMF
• Cipla USA, Inc.USA1 active DMF
• HEC PHARM COChina1 active DMF
• PHARMAZELL INDIA PRIVATE LTDIndia1 active DMF
• Laurus Labs LimitedIndia1 active DMF
• CHONGQING CARELIFE PHARMACEUTICAL CO LTDChina1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Tenofovir Alafenamide expires 15 Feb 2033 and exclusivity 27 Mar 2027. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate

Canonical SMILES

C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3

InChIKey

LDEKQSIMHVQZJK-CAQYMETFSA-N