Nalmefene

Overview

Nalmefene is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL982).

API suppliers (1)

Suppliers of Nalmefene evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• PURISYS LLCUnited States1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (5 approved US products), the latest listed US patent on Nalmefene expires 4 Aug 2042 and exclusivity 7 Aug 2027. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol

Canonical SMILES

C=C1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O

InChIKey

WJBLNOPPDWQMCH-MBPVOVBZSA-N