Plecanatide

Overview

Plecanatide is a synthetic analog of uroguanylin, a natural human peptide, which activates guanylate cyclase-C on the luminal surface of intestinal epithelial cells to stimulate cGMP production, leading to increased intestinal fluid secretion and transit. It is used in the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C).

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Plecanatide expires 4 Jun 2034. Generic API sourcing typically opens up once these lapse.

Therapeutic areas