Plecanatide
Overview
Plecanatide is a synthetic analog of uroguanylin, a natural human peptide, which activates guanylate cyclase-C on the luminal surface of intestinal epithelial cells to stimulate cGMP production, leading to increased intestinal fluid secretion and transit. It is used in the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C).
API suppliers (6)
Suppliers of Plecanatide evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.
Country recorded for 3 of 6 suppliers.
2 of 6 hold a GMP certificate on record in the EU or UK registers
- CHUNGHWA CHEMICAL SYNTHESIS AND BIOTECH CO LTD1 active DMF GMP on record
- MSN LIFE SCIENCES PRIVATE LIMITEDIndia1 active DMF GMP on record
- MATRIX PHARMACORP PRIVATE LTDIndia1 active DMF
- ALP PHARM BEIJING CO LTD1 active DMF
- AURO PEPTIDES LTD1 active DMF
- Hybio Pharmaceutical Co., Ltd.China1 active DMF
Patent & exclusivity (US)
Per the FDA Orange Book (1 approved US product), the latest listed US patent on Plecanatide expires 5 Jun 2034. Generic API sourcing typically opens up once these lapse.
Therapeutic areas
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