Methotrexate

Overview

Methotrexate is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL34259).

API suppliers (16)

Suppliers of Methotrexate backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• FERMION OYFinland2 active DMF
• EXCELLA GMBH AND CO KG1 active DMF
• EXCELLA GMBH AND CO KG1 active DMF
• GNT Pharma Co., Ltd.South Korea1 active DMF
• HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL CO LTDChina1 active DMF
• EXCELLA GMBH AND CO KG1 active DMF
• HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL CO LTDChina1 active DMF
• Pfizer LimitedIndia
• BEN VENUE LABORATORIES INC
• SUMIKA FINE CHEMICALS CO LTD
• Zhejiang Hisun Pharmaceutical Co., Ltd.China
• BENZOCHEM LIFESCIENCES PVT LTD
• LIANYUNGANG PHARMACEUTICAL FACTORY
• PFANSTIEHL LABORATORIES INC
• MONSANTO CO
• SEACROSS PHARMA USA INC

Patent & exclusivity (US)

Per the FDA Orange Book (50 approved US products), the latest listed US patent on Methotrexate expires 27 Oct 2035. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid

Canonical SMILES

CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

InChIKey

FBOZXECLQNJBKD-ZDUSSCGKSA-N