Mannitol

Overview

Mannitol is a naturally occurring sugar alcohol used as a medication and osmoregulatory agent. It is primarily utilized in the clinical setting to decrease intracranial pressure and treat oliguria.

API suppliers (5)

Suppliers of Mannitol evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• ROQUETTE FRERESFrance1 active DMF
• SHANDONG TIANLI PHARMACEUTICAL CO LTD1 active DMF
• GUANGDONG HUANFA PHARMACEUTICAL CO LTD1 active DMF
• SAN FU CHEMICAL CO LTD
• CORN PRODUCTS BRASIL INGREDIENTS INDUSTRIAIS LTDA

Patent & exclusivity (US)

Per the FDA Orange Book (17 approved US products), the latest listed US patent on Mannitol expires — and exclusivity 30 Oct 2027. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol

Canonical SMILES

C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O

InChIKey

FBPFZTCFMRRESA-KVTDHHQDSA-N

Therapeutic areas