Lorazepam

Overview

Lorazepam is a benzodiazepine used to treat anxiety disorders, insomnia, and is used as a premedication for sedation. It works by increasing the activity of a certain neurotransmitter in the brain.

API suppliers (12)

Suppliers of Lorazepam evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• FIS FABBRICA ITALIANA SINTETICI SPAItaly1 active DMF GMP on record
• EVONIK OPERATIONS GMBHGermany1 active DMF GMP on record
• STHREE CHEMICALS PRIVATE LTD1 active DMF
• CENTAUR PHARMACEUTICALS PVT LTDIndia1 active DMF GMP on record
• MALLADI DRUGS AND PHARMACEUTICALS LTDIndia1 active DMF
• RL FINE CHEM PVT LTDIndia1 active DMF
• CAMBREX PROFARMACO MILANO SRLItaly1 active DMF GMP on record
• KALINTIS HEALTHCARE PVT LTDIndia1 active DMF
• Sun Pharmaceutical Industries LimitedIndia GMP on record
• Teva Pharmaceutical Industries Ltd.Israel GMP on record
• SANDOZ LTD PHARMACEUTICAL DIV CHEMICAL DEVELOPMENT
• Cipla USA, Inc.USA

Patent & exclusivity (US)

Per the FDA Orange Book (41 approved US products), the latest listed US patent on Lorazepam expires 8 Jan 2034. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one

Canonical SMILES

C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl

InChIKey

DIWRORZWFLOCLC-UHFFFAOYSA-N

Therapeutic areas