Lomitapide

Overview

Lomitapide is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL354541).

Patent & exclusivity (US)

Per the FDA Orange Book (5 approved US products), the latest listed US patent on Lomitapide expires 28 Jul 2041 and exclusivity 25 Feb 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide

Canonical SMILES

C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F

InChIKey

MBBCVAKAJPKAKM-UHFFFAOYSA-N