Clozapine

Overview

Clozapine is an atypical antipsychotic used for the treatment of resistant schizophrenia and for reducing the risk of suicidal behavior in people with schizophrenia. It works by blocking various neurotransmitter receptors in the brain, particularly serotonin and dopamine receptors.

API suppliers (15)

Suppliers of Clozapine evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• SHANGHAI ZHONGXI SUNVE PHARMACEUTICAL CO LTDChina1 active DMF
• CAMBREX PROFARMACO MILANO SRLItaly1 active DMF GMP on record
• SHOUGUANG FUKANG PHARMACEUTICAL CO LTDChina1 active DMF GMP on record
• MATRIX PHARMACORP PRIVATE LTDIndia1 active DMF
• COHANCE LIFESCIENCES LTDIndia1 active DMF GMP on record
• GLOBAL CALCIUM PRIVATE LTDIndia1 active DMF GMP on record
• Mankind Pharma LimitedIndia1 active DMF GMP on record
• R L Fine Chem Pvt. Ltd.India1 active DMF
• SMS Pharmaceuticals limitedIndia1 active DMF GMP on record
• AURORE LIFE SCIENCES PRIVATE LTD1 active DMF GMP on record
• MEDICHEM SASpain1 active DMF GMP on record
• WUHAN SHIJI PHARMACEUTICAL CO LTD1 active DMF
• SELOC FRANCE
• SANDOZ LTD PHARMACEUTICAL DIV CHEMICAL DEVELOPMENT
• Arevipharma GmbHGermany GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (34 approved US products), the latest listed US patent on Clozapine expires 1 May 2028. Generic API sourcing typically opens up once these lapse.

Therapeutic areas