Voclosporin

Overview

Voclosporin is a protein active pharmaceutical ingredient (ChEMBL CHEMBL5314379).

API suppliers (8)

Suppliers of Voclosporin evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• TAPI NL BVNetherlands1 active DMF
• Lonza Group AGSwitzerland1 active DMF
• BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO LTDChina1 active DMF
• MEDICHEM SASpain1 active DMF GMP on record
• CONCORD BIOTECH LTDIndia1 active DMF GMP on record
• INDENA SPAItaly1 active DMF GMP on record
• DR REDDYS LABORATORIES LTD1 active DMF GMP on record
• HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL CO LTDChina1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Voclosporin expires 7 Dec 2037 and exclusivity 22 Jan 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhepta-4,6-dienyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

Canonical SMILES

CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C=C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

InChIKey

BICRTLVBTLFLRD-PTWUADNWSA-N