Vepdegestrant

Overview

Vepdegestrant is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL5095210).

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Vepdegestrant expires 30 Jan 2038 and exclusivity 1 May 2031. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(3S)-3-[6-[4-[[1-[4-[(1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]phenyl]piperidin-4-yl]methyl]piperazin-1-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

Canonical SMILES

C1CC2=C(C=CC(=C2)O)[C@H]([C@H]1C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CC5)CN6CCN(CC6)C7=CC8=C(C=C7)C(=O)N(C8)[C@H]9CCC(=O)NC9=O

InChIKey

TZZDVPMABRWKIZ-XMOGEVODSA-N