Venetoclax

Overview

Venetoclax is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL3137309).

API suppliers (8)

Suppliers of Venetoclax evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• Porton Pharma Solutions Ltd.China1 active DMF
• Alembic Pharmaceuticals LimitedIndia1 active DMF GMP on record
• MSN Laboratories Private LimitedIndia1 active DMF GMP on record
• Hetero Labs LimitedIndia1 active DMF GMP on record
• CHANGZHOU PHARMACEUTICAL FACTORYChina1 active DMF GMP on record
• Natco PharmaIndia1 active DMF GMP on record
• XUZHOU WANBANG JINQIAO PHARMA CO LTDChina1 active DMF
• DR REDDYS LABORATORIES LTD1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (6 approved US products), the latest listed US patent on Venetoclax expires 6 Sept 2033 and exclusivity 15 May 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide

Canonical SMILES

CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C

InChIKey

LQBVNQSMGBZMKD-UHFFFAOYSA-N