Treprostinil Diolamine

Overview

Treprostinil Diolamine is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2107815).

API suppliers (4)

Suppliers of Treprostinil Diolamine evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• EVERLIGHT CHEMICAL INDUSTRIAL CORPTaiwan1 active DMF
• SS PHARMA LLCIndia1 active DMF
• TIEN (Tianjin) Pharmaceutical Co. LtdChina1 active DMF
• Apotex Inc.Canada1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (5 approved US products), the latest listed US patent on Treprostinil Diolamine expires 11 Aug 2031 and exclusivity 18 Oct 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

2-[[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid;2-(2-hydroxyethylamino)ethanol

Canonical SMILES

CCCCC[C@@H](CC[C@H]1[C@@H](C[C@H]2[C@@H]1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O.C(CO)NCCO

InChIKey

RHWRWEUCEXUUAV-ZSESPEEFSA-N