Trametinib Dimethyl Sulfoxide

Overview

Trametinib Dimethyl Sulfoxide is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2105741).

API suppliers (4)

Suppliers of Trametinib Dimethyl Sulfoxide backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Zakłady Farmaceutyczne Polpharma S.A.Poland1 active DMF
• VALARY LAB PRIVATE LIMITEDIndia1 active DMF
• Biocon LimitedIndia1 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Trametinib Dimethyl Sulfoxide expires 28 Feb 2034 and exclusivity 16 Sept 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;methylsulfinylmethane

Canonical SMILES

CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C

InChIKey

OQUFJVRYDFIQBW-UHFFFAOYSA-N