Trametinib Dimethyl Sulfoxide

CAS 1187431-43-1 4 API suppliersSmall Molecule

Overview

Trametinib Dimethyl Sulfoxide is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2105741).

API suppliers (4)

Suppliers of Trametinib Dimethyl Sulfoxide evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

Where these suppliers are
India2China1

Country recorded for 3 of 4 suppliers.

2 of 4 hold a GMP certificate on record in the EU or UK registers

  • ZAKLADY FARMACEUTYCZNE POLPHARMA SA1 active DMF
  • VALARY LAB PRIVATE LIMITEDIndia1 active DMF GMP on record
  • Biocon LimitedIndia1 active DMF
  • Zhejiang Ausun Pharmaceutical Co., Ltd.China1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Trametinib Dimethyl Sulfoxide expires 28 Feb 2034 and exclusivity 16 Sept 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name
N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;methylsulfinylmethane
Canonical SMILES
CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C
InChIKey
OQUFJVRYDFIQBW-UHFFFAOYSA-N
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