Trabectedin

Overview

Trabectedin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL450449).

API suppliers (3)

Suppliers of Trabectedin backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Pharma Mar, S.A.Spain1 active DMF
• Pharma Mar, S.A.Spain1 active DMF
• Pharma Mar, S.A.Spain1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Trabectedin expires 18 Feb 2043. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[(1R,2R,3R,11S,12S,14R,26R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-3,4-dihydro-2H-isoquinoline]-22-yl] acetate

Canonical SMILES

CC1=CC2=C([C@@H]3[C@@H]4[C@H]5C6=C(C(=C7C(=C6[C@@H](N4[C@H]([C@H](C2)N3C)O)COC(=O)[C@@]8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O

InChIKey

PKVRCIRHQMSYJX-AIFWHQITSA-N