Trabectedin

Overview

Trabectedin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL450449).

API suppliers (6)

Suppliers of Trabectedin evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• MSN Laboratories Private LimitedIndia1 active DMF GMP on record
• APICORE US LLCUnited States1 active DMF
• BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO LTDChina1 active DMF
• EXTROVIS AGSwitzerland1 active DMF
• Chongqing Sintaho Pharmaceutical Co., Ltd.China1 active DMF
• PHARMA MAR SA1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Trabectedin expires 18 Feb 2043. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[(1R,2R,3R,11S,12S,14R,26R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-3,4-dihydro-2H-isoquinoline]-22-yl] acetate

Canonical SMILES

CC1=CC2=C([C@@H]3[C@@H]4[C@H]5C6=C(C(=C7C(=C6[C@@H](N4[C@H]([C@H](C2)N3C)O)COC(=O)[C@@]8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O

InChIKey

PKVRCIRHQMSYJX-AIFWHQITSA-N