Tolvaptan

Overview

Tolvaptan is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL344159).

API suppliers (4)

Suppliers of Tolvaptan backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• OLON SPAItaly1 active DMF
• OLON SPAItaly1 active DMF
• Hetero Drugs LimitedIndia1 active DMF
• Lupin LimitedIndia1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (33 approved US products), the latest listed US patent on Tolvaptan expires 6 Apr 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide

Canonical SMILES

CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C

InChIKey

GYHCTFXIZSNGJT-UHFFFAOYSA-N