Tofacitinib

Overview

Tofacitinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL221959).

API suppliers (3)

Suppliers of Tofacitinib backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• METROCHEM API PRIVATE LTD2 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China2 active DMF
• SINTENOVO SA DE CV

Patent & exclusivity (US)

Per the FDA Orange Book (42 approved US products), the latest listed US patent on Tofacitinib expires 13 Sept 2034 and exclusivity 20 Aug 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile

Canonical SMILES

C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N

InChIKey

UJLAWZDWDVHWOW-YPMHNXCESA-N