Terlipressin

Overview

Terlipressin is a protein active pharmaceutical ingredient (ChEMBL CHEMBL2135460).

API suppliers (5)

Suppliers of Terlipressin evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• PolyPeptide Laboratories (Sweden) ABSweden1 active DMF GMP on record
• HARBIN JIXIANGLONG BIOTECH CO LTD1 active DMF
• CHENGDU SHENGNUO BIOPHARM CO LTDChina1 active DMF
• Cipla USA, Inc.USA1 active DMF
• Piramal Pharma LimitedIndiaCEP GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Terlipressin expires 5 Apr 2037 and exclusivity 14 Sept 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide

Canonical SMILES

C1C[C@H](N(C1)C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N

InChIKey

BENFXAYNYRLAIU-QSVFAHTRSA-N