Temsirolimus

Overview

Temsirolimus is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1201182).

API suppliers (6)

Suppliers of Temsirolimus evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• CONCORD BIOTECH LTDIndia1 active DMF GMP on record
• Sandoz LtdUnited Kingdom1 active DMF
• Shandong New Time Pharmaceutical Co Ltd1 active DMF GMP on record
• Sun Pharmaceutical Industries LimitedIndia1 active DMF GMP on record
• FRESENIUS KABI ONCOLOGY LTDIndia GMP on record
• Biocon LimitedIndia

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Temsirolimus expires 10 Nov 2032. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl] 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

Canonical SMILES

C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OC(=O)C(C)(CO)CO)C)/C)O)OC)C)C)/C)OC

InChIKey

CBPNZQVSJQDFBE-FUXHJELOSA-N