Temsirolimus

Overview

Temsirolimus is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1201182).

API suppliers (5)

Suppliers of Temsirolimus backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Sandoz GmbHGermany1 active DMF
• CONCORD BIOTECH LTD1 active DMF
• Sandoz GmbHGermany1 active DMF
• Biocon LimitedIndia
• FRESENIUS KABI ONCOLOGY LTD

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Temsirolimus expires 10 Nov 2032. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl] 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

Canonical SMILES

C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OC(=O)C(C)(CO)CO)C)/C)O)OC)C)C)/C)OC

InChIKey

CBPNZQVSJQDFBE-FUXHJELOSA-N