Talazoparib

Overview

Talazoparib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL3137320).

API suppliers (23)

Suppliers of Talazoparib evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• MSN Laboratories Private LimitedIndia1 active DMF GMP on record
• UNION QUIMICO FARMACEUTICA SA (UQUIFA SA)Spain1 active DMF
• Sun Pharmaceutical Industries LimitedIndia1 active DMF GMP on record
• SHILPA PHARMA LIFESCIENCES LTDIndia1 active DMF
• AARTI PHARMALABS LIMITEDIndia1 active DMF
• TAPI NL BVNetherlands1 active DMF
• DR REDDYS LABORATORIES LTD GMP on record
• FRESENIUS KABI ONCOLOGY LTDIndia GMP on record
• TAI HENG INDUSTRY CO LTD
• Genesen Labs LtdIndia
• SIGNA SA DE CV
• MYLAN LABORATORIES LTD GMP on record
• Emcure Pharmaceuticals LimitedIndia GMP on record
• MAC CHEM PRODUCTS INDIA PVT LTD GMP on record
• USV PRIVATE LTDIndia GMP on record
• Lupin LimitedIndia GMP on record
• KEKULE PHARMA LTDIndia
• Arevipharma GmbHGermany GMP on record
• Zhejiang Hisun Pharmaceutical Co., Ltd.China GMP on record
• CF PHARMA LTD
• Cipla USA, Inc.USA
• EXCELLA GMBH GMP on record
• COSMA SPAItaly GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (6 approved US products), the latest listed US patent on Talazoparib expires 20 Oct 2031 and exclusivity 20 Jun 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one

Canonical SMILES

CN1C(=NC=N1)[C@@H]2[C@H](NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F

InChIKey

HWGQMRYQVZSGDQ-HZPDHXFCSA-N