Sofosbuvir

Overview

Sofosbuvir is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1259059).

API suppliers (1)

Suppliers of Sofosbuvir backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Alembic Pharmaceuticals LimitedIndia1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (4 approved US products), the latest listed US patent on Sofosbuvir expires 10 Jun 2031 and exclusivity 27 Aug 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate

Canonical SMILES

C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

InChIKey

TTZHDVOVKQGIBA-IQWMDFIBSA-N