Sincalide

Overview

Sincalide is a protein active pharmaceutical ingredient (ChEMBL CHEMBL1121).

API suppliers (5)

Suppliers of Sincalide backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• BACHEM INC1 active DMF
• BACHEM INC1 active DMF
• BACHEM INC1 active DMF
• BACHEM INC1 active DMF
• BACHEM AMERICAS INC

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Sincalide expires 19 Apr 2038. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-(4-sulfooxyphenyl)propan-2-yl]amino]-4-oxobutanoic acid

Canonical SMILES

CSCC[C@@H](C(=O)NCC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N)NC(=O)[C@H](CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)[C@H](CC(=O)O)N

InChIKey

IZTQOLKUZKXIRV-YRVFCXMDSA-N