Simvastatin

Overview

Simvastatin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1064).

API suppliers (34)

Suppliers of Simvastatin backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Zhejiang Hisun Pharmaceutical Co., Ltd.China1 active DMF
• Biocon LimitedIndia1 active DMF
• Taro Pharmaceutical Industries Ltd.Israel1 active DMF
• Biocon LimitedIndia1 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China1 active DMF
• Lupin LimitedIndia1 active DMF
• Taro Pharmaceutical Industries Ltd.Israel1 active DMF
• Biocon LimitedIndia1 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China1 active DMF
• Taro Pharmaceutical Industries Ltd.Israel1 active DMF
• JUBILANT BIOSYS LTD1 active DMF
• Biocon LimitedIndia1 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China1 active DMF
• Lupin LimitedIndia1 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China1 active DMF
• Lupin LimitedIndia1 active DMF
• JUBILANT BIOSYS LTD1 active DMF
• SOUTHWEST SYNTHETIC PHARMACEUTICAL CORP LTD1 active DMF
• MYLAN LABORATORIES LTD
• Dr. Reddy's Laboratories Ltd.India
• Sun Pharmaceutical Industries LimitedIndia
• SANDOZ INDUSTRIAL PRODUCTS SPA
• STERLING BIOTECH LTD
• KREBS BIOCHEMICALS INDUSTRIES LTD
• Lek Pharmaceuticals D.D.Slovenia

Showing 25 of 34 suppliers — see the full list in the app.

Patent & exclusivity (US)

Per the FDA Orange Book (60 approved US products), the latest listed US patent on Simvastatin expires 23 Feb 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate

Canonical SMILES

CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C

InChIKey

RYMZZMVNJRMUDD-HGQWONQESA-N