Sevabertinib

Overview

Sevabertinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL6068074).

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Sevabertinib expires 10 Oct 2035 and exclusivity 19 Nov 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

3-(3-chloro-2-methoxyanilino)-2-[3-[[(2S)-1,4-dioxan-2-yl]methoxy]-4-pyridinyl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one

Canonical SMILES

COC1=C(C=CC=C1Cl)NC2=C(NC3=C2C(=O)NCC3)C4=C(C=NC=C4)OC[C@@H]5COCCO5

InChIKey

VYQVHWNNPKOJEA-AWEZNQCLSA-N