Sacubitril/valsartan

Overview

Sacubitril/Valsartan is a combination of sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker, used to reduce the risk of cardiovascular death and hospitalization for heart failure patients with reduced ejection fraction. This combination enhances the protective neurohormonal systems of the heart while suppressing the harmful systems, promoting vasodilation and blood pressure reduction.

API suppliers (7)

Suppliers of Sacubitril/valsartan evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• MATRIX PHARMACORP PRIVATE LTDIndia1 active DMF
• HARMAN FINOCHEM LTDIndia1 active DMF GMP on record
• Macleods Pharmaceuticals Ltd.India1 active DMF GMP on record
• TAPI NL BVNetherlands1 active DMF
• ZHUHAI RUNDU PHARMACEUTICAL CO LTDChina1 active DMF
• AMOLI ORGANICS (A DIVISION OF UMEDICA LABORATORIES PVT LTD)India1 active DMF
• DR REDDYS LABORATORIES LTD1 active DMF GMP on record

Chemical identity

IUPAC name

hexasodium;bis(4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate);bis((2S)-3-methyl-2-[pentanoyl-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]amino]butanoate);pentahydrate

Canonical SMILES

CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[N-]3)[C@@H](C(C)C)C(=O)[O-].CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[N-]3)[C@@H](C(C)C)C(=O)[O-].CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

InChIKey

ZASXKEGREHRXDL-CAWNUZPDSA-H

Therapeutic areas