Rolapitant

Overview

Rolapitant is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL3707331).

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Rolapitant expires 9 Oct 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one

Canonical SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4

InChIKey

FIVSJYGQAIEMOC-ZGNKEGEESA-N