Posaconazole

Overview

Posaconazole is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1397).

API suppliers (3)

Suppliers of Posaconazole backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Biocon LimitedIndia2 active DMF
• OLON SPAItaly1 active DMF
• OLON SPAItaly1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (21 approved US products), the latest listed US patent on Posaconazole expires — and exclusivity 27 Jan 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

Canonical SMILES

CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F

InChIKey

RAGOYPUPXAKGKH-XAKZXMRKSA-N