Posaconazole

Overview

Posaconazole is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1397).

API suppliers (15)

Suppliers of Posaconazole evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• Biocon LimitedIndia2 active DMF
• WUHAN ZY PHARMACEUTICAL CO LTD1 active DMF
• Neuland Laboratories LimitedIndia1 active DMF
• Zhejiang Ausun Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• Apotex Inc.Canada1 active DMF
• COHANCE LIFESCIENCES LTDIndia1 active DMF GMP on record
• QUIMICA SINTETICA SASpain1 active DMF GMP on record
• METROCHEM API PRIVATE LTDIndia1 active DMF
• SHANDONG JINCHENG KUNLUN PHARMACEUTICAL CO LTDChina1 active DMF
• CHROMO LABORATORIES INDIA PRIVATE LTDIndia1 active DMF
• WEINAN MANARECO PHARMACEUTICAL CO LTD1 active DMF
• CHONGQING HUAPONT SHENGCHEM PHARMACEUTICAL CO LTDChina1 active DMF
• Sichuan Kelun Pharmaceutical Co., Ltd.China1 active DMF
• OLON SPAItaly1 active DMF GMP on record
• DR REDDYS LABORATORIES LTD1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (22 approved US products), the latest listed US patent on Posaconazole expires — and exclusivity 27 Jan 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

Canonical SMILES

CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F

InChIKey

RAGOYPUPXAKGKH-XAKZXMRKSA-N