Phentolamine

Overview

Phentolamine is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL597).

API suppliers (3)

Suppliers of Phentolamine evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• MATRIX PHARMACORP PRIVATE LTDIndia2 active DMF
• APICORE LLC (A WHOLLY OWNED SUB OF RK PHARMA INC)1 active DMF
• RELIABLE BIOPHARMACEUTICAL CORPUnited States1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (4 approved US products), the latest listed US patent on Phentolamine expires 25 Oct 2039 and exclusivity 25 Sept 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol

Canonical SMILES

CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O

InChIKey

MRBDMNSDAVCSSF-UHFFFAOYSA-N