Pexidartinib

Overview

Pexidartinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL3813873).

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Pexidartinib expires 24 Jul 2038 and exclusivity 2 Aug 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)-3-pyridinyl]methyl]pyridin-2-amine

Canonical SMILES

C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F

InChIKey

JGWRKYUXBBNENE-UHFFFAOYSA-N