Pemetrexed

Overview

Pemetrexed is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL225072).

API suppliers (15)

Suppliers of Pemetrexed evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• MSN Laboratories Private LimitedIndia3 active DMF GMP on record
• SHILPA PHARMA LIFESCIENCES LTDIndia2 active DMF
• DR REDDYS LABORATORIES LTD2 active DMF GMP on record
• Jiangsu Hansoh Pharmaceutical Group Company LimitedChina2 active DMF GMP on record
• SCINOPHARM TAIWAN LTDTaiwan2 active DMF
• Sun Pharmaceutical Industries LimitedIndia1 active DMF GMP on record
• POLYMED THERAPEUTICS INC1 active DMF
• Gland Chemicals Private LimitedIndia1 active DMF
• RAVI BIOLIFE PRIVATE LTDIndia1 active DMF
• CDYMAX (INDIA) PHARMA PRIVATE LIMITEDIndia1 active DMF GMP on record
• Hetero Labs LimitedIndia1 active DMF GMP on record
• Suzhou Lixin Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• ITF CHEMICAL LTDABrazil
• CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO LTD
• Neuland Laboratories LimitedIndia

Patent & exclusivity (US)

Per the FDA Orange Book (52 approved US products), the latest listed US patent on Pemetrexed expires 19 Feb 2036. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid

Canonical SMILES

C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O

InChIKey

WBXPDJSOTKVWSJ-ZDUSSCGKSA-N