Pemetrexed

Overview

Pemetrexed is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL225072).

API suppliers (19)

Suppliers of Pemetrexed backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• MSN Laboratories Private LimitedIndia3 active DMF
• CHONGQING CARELIFE PHARMACEUTICAL CO LTDChina2 active DMF
• WUHAN CALMLAND PHARMACEUTICALS CO LTDChina2 active DMF
• Jiangsu Hansoh Pharmaceutical Group Company LimitedChina2 active DMF
• SHILPA PHARMA LIFESCIENCES LTD2 active DMF
• SCINOPHARM TAIWAN LTD2 active DMF
• Dr. Reddy's Laboratories Ltd.India2 active DMF
• CHEMWERTH INC1 active DMF
• POSH CHEMICALS PRIVATE LTD1 active DMF
• Siam Pharmaceutical Co., Ltd.Thailand1 active DMF
• SHANDONG XINHUA PHARMACEUTICAL CO LTDChina1 active DMF
• CHEMWERTH INC1 active DMF
• POSH CHEMICALS PRIVATE LTD1 active DMF
• CTX LIFE SCIENCES PVT LTD1 active DMF
• Siam Pharmaceutical Co., Ltd.Thailand1 active DMF
• CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO LTD
• Neuland Laboratories LimitedIndia
• MYLAN LABORATORIES LTD
• ITF CHEMICAL LTDABrazil

Patent & exclusivity (US)

Per the FDA Orange Book (52 approved US products), the latest listed US patent on Pemetrexed expires 19 Feb 2036. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid

Canonical SMILES

C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O

InChIKey

WBXPDJSOTKVWSJ-ZDUSSCGKSA-N