Palovarotene

Overview

Palovarotene is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2105648).

Patent & exclusivity (US)

Per the FDA Orange Book (5 approved US products), the latest listed US patent on Palovarotene expires 8 Jun 2037 and exclusivity 16 Aug 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid

Canonical SMILES

CC1(CCC(C2=C1C=C(C(=C2)/C=C/C3=CC=C(C=C3)C(=O)O)CN4C=CC=N4)(C)C)C

InChIKey

YTFHCXIPDIHOIA-DHZHZOJOSA-N