Pacritinib

CAS 937272-79-2Small Molecule

Overview

Pacritinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2035187).

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Pacritinib expires 25 Mar 2030 and exclusivity 28 Feb 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name
(16E)-11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(24),2(27),3,5,8(26),9,11,16,21(25),22-decaene
Canonical SMILES
C1CCN(C1)CCOC2=C3COC/C=C/COCC4=CC(=CC=C4)C5=NC(=NC=C5)NC(=C3)C=C2
InChIKey
HWXVIOGONBBTBY-ONEGZZNKSA-N
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