Orforglipron

Overview

Orforglipron is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL4446782).

API suppliers (5)

Suppliers of Orforglipron evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• SINOPEP-ALLSINO BIOPHARMACEUTICAL CO LTDChina1 active DMF
• Allsino Pharmaceutical Co., Ltd.China1 active DMF
• NINGXIA LABSCHEM CO LTDChina1 active DMF
• El-Peptido (Shanghai) Biopharmaceutical Co., LtdChina1 active DMF
• FUJIAN GENOHOPE BIOTECH LTDChina1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (6 approved US products), the latest listed US patent on Orforglipron expires 26 Sept 2037 and exclusivity 1 Apr 2031. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one

Canonical SMILES

C[C@H]1C[C@]1(C2=NOC(=O)N2)N3C4=C(C=C(C=C4)[C@H]5CCOC(C5)(C)C)C=C3C(=O)N6CCC7=NN(C(=C7[C@@H]6C)N8C=CN(C8=O)C9=C(C1=C(C=C9)N(N=C1)C)F)C1=CC(=C(C(=C1)C)F)C

InChIKey

USUWIEBBBWHKNI-KHIFEHGGSA-N