Omaveloxolone

Overview

Omaveloxolone is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL4303525).

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Omaveloxolone expires 24 Apr 2033 and exclusivity 28 Feb 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

N-[(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicen-4a-yl]-2,2-difluoropropanamide

Canonical SMILES

C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)NC(=O)C(C)(F)F

InChIKey

RJCWBNBKOKFWNY-IDPLTSGASA-N