Nirogacestat

Overview

Nirogacestat is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1770916).

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Nirogacestat expires 19 May 2043 and exclusivity 27 Nov 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide

Canonical SMILES

CCC[C@@H](C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)N[C@H]2CCC3=C(C2)C(=CC(=C3)F)F

InChIKey

VFCRKLWBYMDAED-REWPJTCUSA-N