Nicardipine

Overview

Nicardipine is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1484).

API suppliers (10)

Suppliers of Nicardipine evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• CHEMWERTH INCFrance1 active DMF
• NAVINTA LLCUnited States1 active DMF
• LUSOCHIMICA SPAItaly1 active DMF GMP on record
• GLAND PHARMA LTDIndia1 active DMF GMP on record
• MSN Laboratories Private LimitedIndia1 active DMF GMP on record
• Qilu Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• Zhejiang Huahai Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• MAHI DRUGS PRIVATE LIMITEDIndia1 active DMF
• METROCHEM API PRIVATE LTDIndia1 active DMF
• MAITHRI DRUGS PRIVATE LTDIndia1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (33 approved US products), the latest listed US patent on Nicardipine expires 26 Dec 2027. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Canonical SMILES

CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC

InChIKey

ZBBHBTPTTSWHBA-UHFFFAOYSA-N