Neratinib

Overview

Neratinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL180022).

API suppliers (2)

Suppliers of Neratinib backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• TAPI NL BV1 active DMF
• TAPI NL BV1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Neratinib expires 17 Jul 2031. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

Canonical SMILES

CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)C

InChIKey

JWNPDZNEKVCWMY-VQHVLOKHSA-N