Moxidectin

Overview

Moxidectin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2104415).

API suppliers (2)

Suppliers of Moxidectin evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• LIVZON NEW NORTH RIVER PHARMACEUTICAL CO LTDChina1 active DMF
• LIVZON GROUP FUZHOU FUXING PHARMACEUTICAL CO LTD1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Moxidectin expires — and exclusivity 7 Feb 2032. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(1R,4S,4'E,5'S,6R,6'S,8R,10E,13R,14E,16E,20R,21R,24S)-21,24-dihydroxy-4'-methoxyimino-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one

Canonical SMILES

C[C@@H]\1C/C(=C/C[C@@H]2C[C@@H](C[C@@]3(O2)C/C(=N\OC)/[C@@H]([C@H](O3)/C(=C/C(C)C)/C)C)OC(=O)[C@@H]4C=C([C@H]([C@@H]5[C@]4(/C(=C/C=C1)/CO5)O)O)C)/C

InChIKey

YZBLFMPOMVTDJY-LSGXYNIPSA-N