Micafungin

Overview

Micafungin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL457547).

API suppliers (4)

Suppliers of Micafungin evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO LTDChina3 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• YUNG SHIN PHARMACEUTICAL INDUSTRIAL CO LTD1 active DMF
• MSN LIFE SCIENCES PRIVATE LIMITEDIndia1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (27 approved US products), the latest listed US patent on Micafungin expires 15 Dec 2037. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[5-[(1S,2S)-2-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-3-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-11,20,21,25-tetrahydroxy-15-[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-18-[[4-[5-(4-pentoxyphenyl)-1,2-oxazol-3-yl]benzoyl]amino]-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-6-yl]-1,2-dihydroxyethyl]-2-hydroxyphenyl] hydrogen sulfate

Canonical SMILES

CCCCCOC1=CC=C(C=C1)C2=CC(=NO2)C3=CC=C(C=C3)C(=O)N[C@H]4C[C@H]([C@H](NC(=O)[C@@H]5[C@H]([C@H](CN5C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC4=O)[C@@H](C)O)O)[C@@H]([C@H](C7=CC(=C(C=C7)O)OS(=O)(=O)O)O)O)[C@@H](CC(=O)N)O)C)O)O)O

InChIKey

PIEUQSKUWLMALL-YABMTYFHSA-N