Methylnaltrexone

Overview

Methylnaltrexone is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1186579).

API suppliers (2)

Suppliers of Methylnaltrexone backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• SPECGX LLCUnited States1 active DMF
• SPECGX LLCUnited States1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (4 approved US products), the latest listed US patent on Methylnaltrexone expires 10 Mar 2031. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7-one

Canonical SMILES

C[N+]1(CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O)CC6CC6

InChIKey

JVLBPIPGETUEET-GAAHOAFPSA-O