Lotilaner

Overview

Lotilaner is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL3707310).

API suppliers (1)

Suppliers of Lotilaner evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• BIOPHORE INDIA PHARMACEUTICALS PVT LTD1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Lotilaner expires 14 Dec 2038 and exclusivity 24 Jul 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide

Canonical SMILES

CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

InChIKey

HDKWFBCPLKNOCK-SFHVURJKSA-N