Lorlatinib

Overview

Lorlatinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL3286830).

API suppliers (1)

Suppliers of Lorlatinib backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Sun Pharmaceutical Industries LimitedIndia1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Lorlatinib expires 4 Oct 2038 and exclusivity 3 Mar 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile

Canonical SMILES

C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C

InChIKey

IIXWYSCJSQVBQM-LLVKDONJSA-N