Lonafarnib
CAS 193275-84-2Small Molecule
Overview
Lonafarnib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL298734).
Patent & exclusivity (US)
Per the FDA Orange Book (2 approved US products), the latest listed US patent on Lonafarnib expires 26 Jul 2029 and exclusivity 20 Nov 2027. Generic API sourcing typically opens up once these lapse.
Chemical identity
- IUPAC name
- 4-[2-[4-[(2R)-6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide
- Canonical SMILES
- C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N
- InChIKey
- DHMTURDWPRKSOA-RUZDIDTESA-N
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