Levoketoconazole

Overview

Levoketoconazole is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL295698).

API suppliers (16)

Suppliers of Levoketoconazole evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• Piramal Pharma LimitedIndia2 active DMF GMP on record
• DERIVADOS QUIMICOS SAUSpain1 active DMF
• STHREE CHEMICALS LLCIndia1 active DMF
• OLON SPAItaly1 active DMF GMP on record
• QUIMICA SINTETICA SASpain1 active DMF GMP on record
• UNION QUIMICO FARMACEUTICA SA (UQUIFA SA)Spain1 active DMF
• SHARON BIO MEDICINE LTDIndia1 active DMF GMP on record
• SS PHARMA LLCIndia1 active DMF
• Torrent PharmaceuticalsIndia1 active DMF GMP on record
• FDC LimitedIndia GMP on record
• ESTEVE QUIMICA SA GMP on record
• ALBEMARLE CORPUnited States
• QUIMICA FINA FARMEX SA DE CV
• NAPP TECHNOLOGIES INCUnited States
• GUFIC BIOSCIENCES LTD GMP on record
• RECORDATI ESPANA SL

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Levoketoconazole expires 2 Mar 2040 and exclusivity 30 Dec 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

1-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone

Canonical SMILES

CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@@H]3CO[C@@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

InChIKey

XMAYWYJOQHXEEK-ZEQKJWHPSA-N